Restoring metabolic balance AND WEIGHT CONTROL

Harnessing precision-targeted drug formulations for the treatment and prevention of metabolic disorders such as obesity and related diseases

Our Approach

Metabolic disorders such as obesity or type 2 diabetes have emerged as a health and economic problem of global proportions, largely due to excessive consumption of calorie-rich highly refined food, sedentary lifestyles, and disruptions to circadian rhythms in modern work and living environments.

Aphaia is committed to offering patients therapeutic options that provide long-term benefits with minimal or no side effects by restoring the body’s natural physiology.

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APH-012

LEAD DRUG CANDIDATE

We believe that our drug lead candidate, a proprietary oral glucose formulation, has the potential to revolutionize the treatment of metabolic disorders like obesity, type 2 diabetes, and associated diseases by addressing the underlying disease mechanism. It uniquely activates nutrient-sensing cells in the distal small intestine, restoring the endogenous release of the full spectrum of enteral hormones that control appetite, hunger, satiety, glucose metabolism, and other homeostatic functions.

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Programs

PHASE 2 TRIALS IN OBESITY AND PREDIABETES

Aphaia’s lead drug candidate is being evaluated in two Phase 2 trials. The first proof-of-concept study in individuals with obesity evaluates its ability to change weight and other key parameters, hallmarking multiple metabolic diseases associated with obesity in a placebo-controlled design. The second trial is evaluating the drug’s ability to help prevent type 2 diabetes.

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News

Aphaia Pharma in Panel Discussion at the 1st Annual BioPharma Obesity Innovation Forum

12/19/2024

Aphaia Pharma to Participate in Panel Discussion at the 1^st Annual BioPharma Obesity Innovation Forum in San Francisco

ZUG, Switzerland, SAN JUAN, Puerto Rico and TORONTO, December 19, 2024 – Aphaia Pharma, a clinical-stage company harnessing precision-targeted drug formulations to restore endogenous endocrine balance for the treatment of obesity and associated metabolic diseases, today announced that Steffen-Sebastian Bolz, MD, Ph.D., Chief Scientific Officer of Aphaia Pharma, will participate in a panel discussion at the 1^st Annual BioPharma Obesity Innovation Forum, taking place January 11, 2025, in San Francisco, California.

Aphaia Pharma to Participate at the 1st Annual Obesity & Metabolic Innovation Forum

11/25/2024

Aphaia Pharma to Participate in a Panel Discussion at the 1^st Annual Obesity & Metabolic Innovation Forum

ZUG, Switzerland, SAN JUAN, Puerto Rico and TORONTO, November 25, 2024 – Aphaia Pharma, a clinical-stage company harnessing precision-targeted drug formulations to restore endogenous endocrine balance for the treatment of obesity and associated metabolic diseases, today announced that Steffen-Sebastian Bolz, MD, Ph.D., Chief Scientific Officer of Aphaia Pharma, will participate in a panel discussion at the 1^st Annual Obesity & Metabolic Innovation Forum, taking place December 4, 2024, in Boston, Massachusetts.

Aphaia Pharma Announces Positive Results from Phase 2 Trial Evaluating its Lead Drug Formulation

06/20/2024

Aphaia Pharma Announces Positive Results from Phase 2 Trial Evaluating its Lead Drug Formulation for Prediabetes Treatment

Primary endpoint met, showing that APHD-012 improves glucose tolerance in individuals with a pathological oral glucose tolerance test (OGTT) after 6 weeks of administration
The results provide proof-of-concept for clinical efficacy of Aphaia’s oral glucose formulation, designed to restore endogenous nutrient-sensing pathways in the gastrointestinal tract
The study confirms that APHD-012 is well tolerated, with no serious adverse events observed
Additional results from a Phase 2 trial evaluating Aphaia’s formulation in individuals with obesity are expected in H2 2024

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